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Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 132-142 doi: 10.1007/s11684-022-0938-x

Abstract: Nasopharyngeal carcinoma (NPC) is a malignant tumor that mainly occurs in East and Southeast Asia.

Keywords: nasopharyngeal carcinoma     WGCNA     RFC4     proliferation    

A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngealcarcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 275-289 doi: 10.1007/s11684-022-0945-y

Abstract: In this study, we used HER kinases as targets for the treatment of nasopharyngeal carcinoma (NPC) and

Keywords: epidermal growth factor receptor     ErbB receptors     HM781-36B     nasopharyngeal carcinoma     molecular targeted    

Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome

Lijuan Hu,Zhirui Lin,Yanheng Wu,Juqin Dong,Bo Zhao,Yanbing Cheng,Peiyu Huang,Lihua Xu,Tianliang Xia,Dan Xiong,Hongbo Wang,Manzhi Li,Ling Guo,Elliott Kieff,Yixin Zeng,Qian Zhong,Musheng Zeng

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 61-75 doi: 10.1007/s11684-016-0436-0

Abstract:

The latent expression pattern of Epstein-Barr Virus (EBV) genes in nasopharyngeal carcinoma (NPC)

Keywords: Epstein-Barr virus     paired-end transcriptome sequencing     latency genes     lytic genes     nasopharyngeal carcinoma    

Alcohol and tea consumption in relation to the risk of nasopharyngeal carcinoma in Guangdong, China

Hong-Lian RUAN, Feng-Hua XU, Wen-Sheng LIU, Qi-Sheng FENG, Li-Zhen CHEN, Yi-Xin ZENG, Wei-Hua JIA,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 448-456 doi: 10.1007/s11684-010-0280-6

Abstract: To investigate whether alcohol and tea consumption has an etiological association with nasopharyngealcarcinoma (NPC) in a high-incident population, a large scale case-control study was conducted.

Keywords: nasopharyngeal carcinoma     case-control study     alcohol consumption     tea consumption    

Technetium-99m-sestamibi SPECT for the diagnosis and follow-up of nasopharyngeal carcinoma

Jing CHEN MD, Guang-Yuan HU MD, Guo-Qing HU MD, Hua WU PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 96-100 doi: 10.1007/s11684-010-0001-1

Abstract: This study was to investigate a better way to detect and differentiate primary, residual, recurrent nasopharyngealcarcinoma (NPC) lesions post-radiotherapy in patients with NPC by means of routine computed tomography

Keywords: nasopharyngeal carcinoma     diagnosis     follow-up    

Effects of Three-Dimensional Platform Stiffness and Layer Dimensions on Separation of Carcinoma Cells Article

W.G. Zhang, Z.Y. Liu, S.W. Pang

Engineering 2021, Volume 7, Issue 10,   Pages 1426-1435 doi: 10.1016/j.eng.2020.09.010

Abstract: Besides biochemical methods, engineered platforms are effective alternatives for sorting carcinoma cellsIn this work, three-dimensional (3D) biomimetic scaffold platforms were developed to separate nasopharyngealcarcinoma 43 (NPC43) cells from immortalized nasopharyngeal epithelial 460 (NP460) cells based on precisely

Keywords: Cell separation     Cell migration     Nasopharyngeal carcinoma (NPC)     3D scaffold platform    

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine in mice

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 390-395 doi: 10.1007/s11684-009-0087-5

Abstract: We constructed a eukaryotic expression plasmid encoding Epstein-Barr virus latent membrane protein 2 (EBV, LMP2) and evaluated its effects on humoral immunity. First, the encoding sequence of the EBV was amplified from B95−8 cell RNA by reverse transcription polymerase chain reaction (RT-PCR) and then was directionally cloned into eukaryotic expression vector pcDNA3.1. It was employed to evaluate immune response of the mice inoculated doubly with the DNA vaccine. The serum antibody against LMP2 was detected with enzyme-linked immunosorbent assay (ELISA). The recombinant plasmid pcDNA3.1- was confirmed by the restrictive endonuclease analysis and sequence analysis. The serum titer of IgG antibody against LMP2 epitope in the mice immunized with the DNA vaccine encoding LMP2 was up to 1∶4000. In conclusion, the EBV DNA vaccine can induce a strong humoral immune response in mice.

Keywords: Epstein-Barr virus     latent membrane protein 2     nasopharyngeal carcinoma     humoral immunity    

The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 33-41 doi: 10.1007/s11684-013-0301-3

Abstract:

Hypoxia is a common phenomenon in hepatocellular carcinoma (HCC).

Keywords: hypoxia     hepatocellular carcinoma (HCC)     metastasis     hypoxia-inducible factor (HIF)    

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 24-32 doi: 10.1007/s11684-014-0312-8

Abstract: study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma

Keywords: osteopontin (OPN)     hepatocellular carcinoma     metastasis     prognosis     therapeutic target     biomarker     genetic    

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 509-521 doi: 10.1007/s11684-017-0546-3

Abstract:

Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading

Keywords: natural killer cell     hepatocellular carcinoma     immunotherapy    

Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 191-202 doi: 10.1007/s11684-017-0512-0

Abstract:

Primary hepatic carcinoma (PHC) is a common malignant tumor in China.with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic carcinoma

Keywords: traditional Chinese medicine     primary hepatic carcinoma     meta-analysis    

Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 183-190 doi: 10.1007/s11684-016-0440-4

Abstract: coexpression network analysis (WGCNA) to gain insights into the molecular aspects of hepatocellular carcinoma

Keywords: hepatocellular carcinoma     coexpression     module     microarray     prognosis    

Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 273-283 doi: 10.1007/s11684-019-0728-2

Abstract: In terms of global cancer-related deaths, hepatocellular carcinoma (HCC) has the fourth highest mortality

Keywords: hepatocellular carcinoma     tyrosine kinase inhibitor     check point inhibitor     anti-angiogenesis    

A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 112-116 doi: 10.1007/s11684-014-0345-z

Abstract:

Primary neuroendocrine breast carcinoma (NEBC) is a very rare type of breast cancer.

Keywords: neuroendocrine carcinoma     neo-adjuvant therapy     breast    

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 197-203 doi: 10.1007/s11684-009-0036-3

Abstract: of regenerating liver 1 (PRL-1) and phosphatase of regenerating liver 3 (PRL-3) in transitional cell carcinoma

Keywords: transitional cell carcinoma of bladder     phosphatase of regenerating liver 1     phosphatase of regenerating    

Title Author Date Type Operation

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Journal Article

A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngealcarcinoma

Journal Article

Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome

Lijuan Hu,Zhirui Lin,Yanheng Wu,Juqin Dong,Bo Zhao,Yanbing Cheng,Peiyu Huang,Lihua Xu,Tianliang Xia,Dan Xiong,Hongbo Wang,Manzhi Li,Ling Guo,Elliott Kieff,Yixin Zeng,Qian Zhong,Musheng Zeng

Journal Article

Alcohol and tea consumption in relation to the risk of nasopharyngeal carcinoma in Guangdong, China

Hong-Lian RUAN, Feng-Hua XU, Wen-Sheng LIU, Qi-Sheng FENG, Li-Zhen CHEN, Yi-Xin ZENG, Wei-Hua JIA,

Journal Article

Technetium-99m-sestamibi SPECT for the diagnosis and follow-up of nasopharyngeal carcinoma

Jing CHEN MD, Guang-Yuan HU MD, Guo-Qing HU MD, Hua WU PhD,

Journal Article

Effects of Three-Dimensional Platform Stiffness and Layer Dimensions on Separation of Carcinoma Cells

W.G. Zhang, Z.Y. Liu, S.W. Pang

Journal Article

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine in mice

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Journal Article

The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Journal Article

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Journal Article

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Journal Article

Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Journal Article

Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Journal Article

Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Journal Article

A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Journal Article

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Journal Article